At least two people were killed and at least 100 people were injured early Sunday morning when an Amtrak train derailed after colliding with a freight train in SC.
According to authorities, all passengers have been evacuated from the train.
"Karen and I are praying for everyone involved in the Amtrak collision in South Carolina", Pence said.
It was the second major crash for the railroad in less than a week.
Tweet Embed: https://twitter.com/mims/statuses/960104745380741122?ref_src=twsrc%5Etfw #BREAKING: Two fatalities in passenger train versus freight train.More news: Liverpool trio set to feature for U-23s
There were eight crew members and approximately 139 passengers on board.
The National Transportation Safety Board has announced that it will conduct an investigation into the cause of the accident.
Officials also say roughly 5,000 gallons of fuel had spilled as a result of the crash, it is now being cleaned up. The lead Amtrak auto and a few passenger cars derailed.
The injured were in hospitals as emergency responders and police were working on the scene. Anyone seeking info about passengers on Train 91 should call the Amtrak info line at 1-800-523-9101.
Lexington Country's Sheriff Department confirmed the deaths and injuries.
It added: "Amtrak is working to take care of everyone who was on the train, including family members of our passengers and crew". "In December, an Amtrak train careened off the rails in Washington State as it headed into a curve, spilling cars onto a busy highway and killing three people".