Khalid Mehsud was the deputy leader of the banned Tehrik-e Taliban Pakistan, or TPP, which is the main faction of the Pakistani Taliban. Pakistan had offered joint investigation into the Kabul's attacks that Kabul had blamed on the Haqqani Network.
Several top leaders of the TTP and the Afghan Taliban have been killed in USA drone strikes on Pakistani territory.
Details of the latest US drone attack emerged as an Afghan delegation led by the neighboring country's deputy foreign minister, Hekmat Khalil Karzai, opened a new round of wide-ranging talks Friday with Pakistani counterparts in Islamabad.
"I have seen some reports on social media about a drone strike, but I have not heard anything from our relevant security agencies", Faisal said.
The spokesman said Taliban chief Mullah Fazlullah immediately replaced Mehsud with another commander, Mufti Noor Wali.
"The vehicle was destroyed", an intelligence official told The Express Tribune, adding that there were at least three reported drone strikes on the Pak-Afghan border in 24 hours.More news: Woman Fell Asleep With A Headache And Woke Up With British Accent
Mehsud, who had two wives and belonged to the Shobi Khel tribe, was placed on the U.S. Designated Terrorist list in October 2014, according to the Express Tribune. Pakistan denies any links to the spate of recent attacks in the Afghan capital and maintains no Taliban sanctuaries are present on its side of the border.
Militant sources said Wali, known by the nickname Ghar Starga, is a ruthless leader with experience working in Pakistani urban areas including the southern city of Karachi.
Donald Trump's Afghanistan strategy will embroil the United States in a "perpetual war" that is doomed to fail, a senior Pakistani official has warned.
The commander was believed to be sheltering in Khost and had ties to the Haqqani network accused of staging high-profile terrorist attacks against local and US -led forces in Afghanistan.
The border region is off limits to journalists and verifying information independently is hard.