And on this evidence they will need the likes of Sergio Aguero, Kevin de Bruyne and David Silva to be well-rested and in-form if they are to deliver the dream of their Abu Dhabi owners by winning the European Cup for a first time as a number of youngsters and fringe players failed to impress.
The first team have a training session before the game kicks off at Old Trafford and Guardiola will watch the game with his staff, particularly with a game against United in April that could potentially become a title-clincher.
However, the Swiss side did at least manage to restore some pride by ending City's 15-month unbeaten home record last night, thanks to a 2-1 victory at the Etihad.
"I know everyone wants to anticipate the situation and what will happen".
While Guardiola was not unduly concerned about the result, given the tie was virtually decided two weeks ago, he was disappointed with the way his side approached the second half.
"I don't know if the players can be ready, but we are going to work on that these next few days".
Guardiola's side visit struggling Stoke City on Monday as they seek to mount an immediate response to Wednesday's surprise, albeit inconsequential, Champions League loss to Basel.
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It is only the second time in the club's history that they've reached the quarter-finals of the Champions League, having made the semi-finals in 2016.
And while it may not seem like a big defeat in the grand scheme of things, Basel showed that the Premier League leaders aren't invincible at home, giving hope to the teams who stand between them and the title. Bayern Munich also won a Monday cup match against German minnows BSV Schwarz-Weiss Rehden during Guardiola's tenure. That's why we have to be focused on what we have to do.
Manchester City manager Pep Guardiola has been fined £20,000 and warned about his future conduct by the Football Association for wearing a yellow ribbon in support of imprisoned pro-independence Catalan politicians.
"Instead of being here, where we have been fighting for eight months with the weather, we will go there and train the same way but in better conditions", he said.
"And we will see our chairman and be there". Raphael Wicky's men can draw optimism from their last two away games in the competition - wins over CSKA Moscow and Benfica - with striker Dimitri Oberlin netting in each game.
But talks have been put on hold after the former Barcelona boss confirmed that his agent did not fly to Manchester to discuss an extension.
"My agent is not in town".