The PFA's Player of the Year will be announced on 22 April during a special awards ceremony in London. They face competition from Kane, Marcus Rashford and Ryan Sessegnon.
Salah is the favourite for the award.
Former Manchester City defender Joleon Lescott said: 'It is hard to choose but De Bruyne pips Salah because he has helped City win the league'.
Operating primarily on City's left flank, the 22-year-old Sane has really come into his own this season.More news: A New BioShock Game Is Reportedly in the Works
The Egyptian has enjoyed a sensational season since joining the Reds from AS Roma in the summer and he is now also in the race for the Golden Boot having notched in 29 goals so far in the League.
His City team-mate Silva is close behind in both categories, with eight goals and 11 assists.
'My victor is Mo Salah, ' Alan Shearer told the BBC. With Kevin De Bruyne and Mo Salah seeming to be the front runners to win the main award, Kane's 25 goals could see him pick up the young player of the year instead. When you look at the names he has overtaken in terms of his goal-to-game ratio in the Premier League it is remarkable'.
Salah has perhaps been the most impressive new signing of the season, and is set to finish as the Premier League's top scorer.
The final two contenders come from champions-elect Manchester City, with Sane and Silva in the reckoning.
De Bruyne is expected to be City's leading candidate having contributed a league-high 15 assists and seven goals from midfield as Pep Guardiola's have marched towards the title.