Hours earlier, Syrian government-run media said the country's air defenses confronted a new "aggression", shooting down missiles over the central region of Homs and a suburb of Damascus.
"Last night, a false alarm that Syrian air space had been penetrated triggered the blowing of air defence sires and the firing of several missiles", state news agency SANA quoted a military source as saying. Approximately nine missiles reportedly targeted the base; their source isn't yet clear. It also comes roughly a week after two Israeli F-15 fighters targeted another Syria's airbase in Homs province, Tiyas (also known as T-4 Airbase).
A Pentagon spokesman said there was no US military activity in that area at this time.
Observatory chief Rami Abdel Rahman said missiles did not hit any of the air bases.
Separately, a media outlet run by Hezbollah, a pro-Iranian militia, said Syrian government air defenses had shot down three missiles targeting Dumair military airport north east of the capital Damascus.More news: Trump morally unfit to be President: James Comey
Shayrat air base was targeted past year in a US cruise missile attack in response to a chemical attack that killed at least 70 people, including children, on the rebel-held town of Khan Sheikhoun.
"There is no U.S. military activity in that area at this time", Eric Pahond, a Pentagon spokesman said when asked about the strike in Homs.
On Saturday (April 14), Syrian was subjected to a number of strikes as part of tripartite aggression on the Arab country by US, Britain and France.
Israeli interventions: Tel Aviv has carried out multiple airstrikes on Syrian government targets during the conflict.
Israel has also staged strikes in Syria, insisting that Iran, which is hostile to Israel, is increasing its military presence in the country.