The new regulations about hyperandrogenism will compel female athletes whose testosterone levels are above a certain level, like South Africa's Caster Semenya, to take medication if they wish to continue participating in certain events.
In 2011, the IAAF enacted a rule to force athletes with hyperandrogenism to artificially lower their testosterone levels to be eligible to compete.
It added: "The IAAF wants athletes to be incentivised to make the huge commitment and sacrifice required to excel in the sport, and so to inspire new generations to join the sport and aspire to the same excellence".
Those who want to compete are not required to undergo surgery.
In its report it writes: "There is a broad medical and scientific consensus that if these individuals are sensitive to androgens (ie, they have properly-functioning androgen receptors), such very high levels of natural testosterone can increase their muscle mass and strength, as well as their levels of circulating haemoglobin, and so significantly enhance their sporting potential".
The new regulations will come into effect on 1 November.
Semenya, double Olympic and triple world champion over 800m and who completed the 800-1500 double at the Commonwealth Games this month, responded to the new rules on Twitter: "I am 97 per cent sure you don't like me but I'm 100 per cent sure I don't care".More news: Wife Ambushes, Kills Husband's Lover Before Turning the Gun on Herself
"This is about our responsibility to ensure, in simple terms, a level playing field". If they do not, athletes may only be able to compete at the national stage, be forced to race against men, find events for inter-sex athletes (if they are even offered) or give up on the sport, according to the Times.
'This means we need to be clear about competition criteria for those two categories.
Literally Mario argued: "This has nothing to do with the colour of her skin, this is a debate on what to do with intersexed athletes, who have 3 times as much testosterone as normal women". The IAAF views the regulation as a step toward creating "fair and meaningful competition within the female classification".
Similar restrictions brought in by athletics' world governing body, the International Association of Athletics Federations, were suspended following a legal challenge by the Indian sprinter Dutee Chand in 2015.
SASCOC contends that while it respects the processes, it is concerned that the rights, confidentiality and privacy of athletes is being affected.
"Caster is not just an athlete to people of South Africa, she represents their hopes and aspirations".