The broader NSE Nifty ended 0.57 percent lower at 10,618.25 and closed the week with a 0.7 percent fall.
The Sensex opened at 35,257.31 points and closed at 35,103.14 points - down 73.28 points or 0.21 per cent - from its previous close.
On April 30, both the key indices rose on the back of firm global cues along with robust buying in the capital goods, IT and FMCG stocks. According to market analysts, heavy selling pressure was witnessed in the automobile, healthcare and metal stocks.
The Sensex was up by 16.06 points or 0.05 per cent at the Wednesday's closing.
The Sensex has touched a high of 35,357.15 points and a low of 35,113.53 during the intra-day trade.
Market breadth remained negative. on the BSE, 581 stocks declined, 494 stocks gained, while 47 stocks remained unchanged.More news: Bullish Options Prices Pop as Apple Stock Soars
He further said: "Major Asian markets have closed on a negative note barring the Taiwan index".
According to Vinod Nair, Head of Research, Geojit Financial Services: "The global market is trading weak as USA starts trade talk with China while any escalation of trade war will dampen investor's sentiment". "Mixed earnings from corporates and valuation concerns compared to other emerging markets influenced investors to book some profit".
On the currency front, the Indian rupee strengthened by one paise to 66.65 against the United States dollar from its previous close at 66.66. The BSE gauge had lost 73.28 points in the previous session.
Kotak Mahindra Bank (up 5.48 per cent), Zee Entertainment Enterprises (up 3.02 per cent), ITC (up 2.26 per cent), Asian Paints (up 2.11 per cent) and HDFC Bank (up 1.55 per cent) were the top gainers in the Nifty index.
Meanwhile, on a net basis, Domestic Institutional Investors (DIIs) sold shares worth Rs 578.92 crore while Foreign Portfolio Investors (FPIs) too sold the shares to the tune of Rs 148.42 crore on Thursday, a provisional data showed. It finally finished at 34,915.38, down 187.76 points or 0.53 per cent.