Star Wars: "The Force Awakens holds the prize for biggest second weekend, with a mighty $149 million in 2015".
Internationally, Infinity War amassed another $162.6 million, thanks in part to a record breaking $17.6 million opening in Russian Federation, bringing the film's worldwide total to $713.3 million - with China still to come later this month.
"We're in uncharted land", explained comScore senior press analyst Paul Dergarabediansaid "It is an additional weekend number that lots of movies would hope to possess on launching weekend". With a domestic total of $450.8 million, Infinity War is also the second-fastest release to cross the $400 million mark, also behind only The Force Awakens.
Infinity War joined the billion-dollar club on Saturday, its 11th day in release.More news: T20 2018: Mumbai beat Punjab by six wickets
MGM and Lionsgate's Pantelion Films' gender-swapped remake of Garry Marshall's 1987 comedy, "Overboard" scored the highest-grossing opening weekend for Pantelion Films with a better-than-expected $14.8 million from 1,623 theaters.
Third place went to "A Quiet Place", which has grossed $159.9 million in five weeks in theaters, and fourth place to "I Feel Pretty", now up to $37.8 million in weekend three.
Next weekend sees the arrival of Life of the Party starring Melissa McCarthy and the thriller Breaking In starring Gabrielle Union.
The latest juggernaut from Disney/Marvel studios took in an estimated $112.47 million over the weekend, according to boxofficepro.com, on over 4,400 screens.