The two rivals will meet at London Stadium, which has a 55,000 capacity for baseball, next June 29 and 30.
But the London Series 2019 marks the advent of Major League Baseball regular season games in Europe. "This is our most significant endeavor ever in Europe and we look forward to showcasing Major League Baseball in one of the world's great cities".
Major League Baseball has expanded its reach in recent years, hosting games in Japan, Australia, Puerto Rico and most recently in Mexico this past weekend, where the Los Angeles Dodgers and San Diego Padres played a three-game series at Estadio de Beisbol in Monterrey. Two of the most recognizable teams are once again two of the best.
Major League Baseball also announced Tuesday it will open its 2019 regular season with two games between the Oakland Athletics and Seattle Mariners at the Tokyo Dome.
Hal Steinbrenner, Yankees' managing general partner, said: "Bringing these storied teams together for British fans -- who have such a profound appreciation for sports at the highest level -- only adds to the unique allure of one of the world's greatest sporting rivalries".
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Major League Baseball is heading to London.
The Yankees host the Red Sox this week in a three-game series.
The Boston Red Sox World Series win in 2004 ended an 86-year title drought, burying the "Curse of the Bambino", the supposed hoodoo stemming from the Red Sox trading beloved star Babe Ruth to the Yankees.
The British capital hosted its first regular-season National Basketball Association game in 2011.
The deal is similar to those agreed with NFL American Football and NBA basketball, both of which now hold regular fixtures in London.