The accusations, first reported a year ago by the New York Times and the New Yorker, gave rise to the #MeToo movement in which hundreds of women have publicly accused powerful men in business, government and entertainment of misconduct.
Weinstein must also wear an electronic monitor, surrender his passport and can not travel beyond NY or CT.
Weinstein, wearing a dark jacket over a blue sweater and white open-collared shirt and dark jeans, gave a weak smile as police officers escorted him inside a lower Manhattan police station at about 7:25am EDT (1125 GMT).
McGowan accused Weinstein of rape, one of dozens of Hollywood women to accuse the producer of sexual misconduct.
The accusations, first reported previous year by the New York Times and the New Yorker, gave rise to the #MeToo movement in which hundreds of women have publicly accused powerful men in business, government and entertainment of misconduct.
Disgraced Hollywood mogul Harvey Weinstein was formally arrested Friday morning on suspicion of rape, a criminal sex act, sex abuse, and sexual misconduct.
He was given the alternative in court of posting a $10 million bond instead of $1 million cash bail, ordered to surrender his passport and barred from leaving NY or CT without court permission. Joan llluzzi, said as she read the charges in New York Criminal Court.
"The NYPD thanks these fearless survivors for their courage to come forward and seek justice". It was the first criminal case against Weinstein since the revelations about him erupted last October and sparked the cultural "reckoning" that became the MeToo movement.More news: Astros honor shooting victims with 'We Play for Santa Fe' shirts
Weinstein has previously denied all allegations of nonconsensual sex.
Brafman, Weinstein's lawyer, told reporters outside the court that his client will enter a plea of "not guilty" to the charges.
The rape charge relates to a woman who was not identified.
Following scores of sexual harassment complaints alleged against the producer, Weinstein has been undergoing sex-rehab treatment in Arizona and, according to Vanity Fair, additional therapy for "anger management, nutrition, and several addiction-related behaviors".
"Of course (Harvey Weinstein) surrenders on a 3 day weekend - This is a PR trick - announce news when no one is noticing", she said. That makes these first criminal charges against Weinstein possible.
Police in Manhattan have also confirmed they had a credible rape allegation against Weinstein after Boardwalk Empire actress Paz de la Huerta accused him of raping her twice at her NY flat in late 2010. Evans, who was a college student and aspiring actress at the time, had only agreed to a meeting at Weinstein's Tribeca offices because a female casting executive was scheduled to speak with her. "And I'll get to be an eye and so many other victims will get to look him square in the eye and just by being there, represent the fact that we did not want this". She frequently appears on CNN as a legal analyst and is an anchor at the Law & Crime Network, providing live legal analysis on high profile court cases. Brafman also has said that Weinstein was a "principal target" of an investigation being conducted by the USA attorney's office in Manhattan. "I have a visceral need for him to have handcuffs on".
The Women's March also reacted to the news, calling it "an important day in terms of visibility for all women whose lives have been devastated because of the actions of Harvey Weinstein".
Until the scandal, Weinstein was among the most influential forces in American film.
Otherwise, he has been hit by a litany of civil lawsuits and The Weinstein Company - which sacked him - has since filed for bankruptcy.