The Barcelona striker netted his 52nd worldwide goal on his landmark 100th appearance, taking full advantage of a goalkeeping error from a routine corner.
The match-winner against Saudi Arabia, Luis Suarez, is the epitome of Uruguay's fighting spirit.
Barcelona striker Suarez volleyed home from a corner midway through the first half as Oscar Tabarez's side laboured to a 1-0 win in Rostov-on-Don.
Luis Suarez scored the only goal at the Rostov Arena, sweeping in from close range on his 100th appearance for La Celeste.
"We had a lot of the ball and moved it well and we are able to do what we aimed to do, but we conceded a goal in a moment of misfortune and then we didn't have the tools to equalize, even though we didn't really suffer in defense".More news: Trump says he will sign something 'pre-emptive' on immigration
"The goal was special, because I wanted to make up for the other day against Egypt", Suarez said. Edison Kawani would move forward with the ball but he could not escape Saudi Arabian captain Osama Utsawi.
Safah was less complimentary and said that the Saudi players had let their fans down, adding: "They seemed scared whenever they attempted to score any goals". At the beginning of the second half, no team started challenging each other. There was no player to stop Kawani from the left edge.
"It's not about being young or experienced it's due to the needs of the team for this game, and according to my information this is the line-up which will best suit us", Tabarez told a news conference on Tuesday. His coach, Juan Antonio Pizzi, gave Mohammed al-Sahlawi a clear indication of taking off the field in the last ten minutes.
Initially, they sat back and were waiting to hit Uruguay on the counter, which they were successful in through their main attacking outlet Fahad Almuwallad, but not getting any clear-cut chances.
"We controlled the things more at the end of the game, but a ball into your area is always unsafe", he said. They had to go through the goalkeeper but they failed.
Uruguay and Russian Federation both have six points from their opening two matches, putting them into the round of 16.